There are lots of therapeutic approaches for long term constipation. Even so, almost all individuals need to understand what the most operative cure for long term constipation is. To realize the possibility of choice and answer to the question “What is the top-grade cure for long term constipation?” we must consider varied approaches and modes to long term constipation. The most practical cure for long term constipation relies on the comprehension of the causal agents as well as mechanisms of action of individual purgatives. Physicians advocate for utilizing cathartics in the consecutive order such as bulk forming drugs, faecal matter softeners, osmotic laxatives, stimulants, suppositories, and clysters. The ground for this way of use is that evacuants may result in dependence and loss of their activity.  They are also able to induce many side effects and many of them are certainly not the most operational cure for long term constipation.